POLAROGRAPY OF ZN (II)-TOLBUTAMIDE COMPLEX AND ITS PHARMACOLOGICAL STUDY

Author(s): Rakesh Choure* and Neelam Vaidya

Abstract

The formation of complexes of tolbutamide and Zn (II) was studied in aqueous media at pH 3.4±0.1 by polarography and spectroscopy. The polarogram indicated formation of complexes between tolbutamide and Zn (II). Tolbutamide produces a well-defined direct current polarogram and differential pulse polarogram in 1M KCl (supporting electrolyte) at pH 3.4±0.1. The stoichiometry of the Zn (II)-tolbutamide complex is 1:1. Antidiabetic studies on the drug and its metal complex have been performed in albino mice. Revealing the complex to be more potent in antidiabetic activity compared to the parent drug.

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