Author(s): Jai Prakash, Balraj Mittal, Shally awasthi, Khushbu Rani and Neena Srivastava


Diabetes mellitus has reached epidemic level worldwide. South Asians are known for increased predisposition of diabetes which has become an important health problem. Obesity is a well-established risk factor for diabetes mellitus and Insulin resistance. Early detection of reduced insulin sensitivity (IS) and insulin resistance (IR) is need of the time. The aim of the present study was to assess most suitable anthropometric indicator for identifying IR or IS and determine the cutoff points of the most effective indicators. A total of 742 subjects were included in this cross-sectional study. Hormone and glucose levels were estimated using standard protocols. Body mass index (BMI), waist circumference (WC), waist-to-hip ratio, waist-to-height ratio (WHtR) and the HOMA-IS and HOMA-IR were determined. The correlations between the anthropometric indices and IS and IR were determined. ROC analysis was used to determine the areas under the curve (AUC) and cutoff points. Among the obese non diabetic females, WHR (r = -0.386; P = <0.001) showed substantially significant correlation with HOMA-IS (homeostasis model assessment of insulin sensitivity). The ROC curve demonstrated statistical significance for BMI, WC and WHR, and the best cutoff points were 28.06 kg/m2, 94.75 cm and 0.91, respectively. It also showed substantial significance for WHR (AUC = 0.65±0.06; P = 0.021), and the best cutoff points was 0.85 in all studied anthropometric indices. Among the obese non diabetic female, WHR showed substantially greater correlation with IR/IS.

image 10.21746/ijbio.2014.09.006

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