Microwave assisted, solvent-free synthesis of some novel imidazoles of biological interest.

Author(s): Rohit Kumar*, Himanshu Gupta

Abstract

In the present study we have made an attempt to synthesize novel imidazoles and evaluate them as potential therapeutic agent for its anthelmintic and free radical scavenging activity. First, sulfanilamide was condensed with heteryl aldehydes to afford corresponding Schiff’s base. The Schiff’s base further on treatment with ammonium acetate and acetylated / benzoylated isatin using silica gel as solid support yielded corresponding imidazoles. The synthesized compounds were analyzed by physical and analytical data. The synthesized compounds were evaluated for their anthelmintic and free radical scavenging activity. All the synthesized substituted imidazoles have shown moderate to good anthelmintic activity while compound 1b, 2b, 8b, 9b and 10b showed most significant free radical scavenging activity.

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