Inhibitory activity of Acetylcholinesterase (AChE) and Antioxidant activity of methanolic extract of Desmodium gangeticum (L.)

Author(s): Navi Ranjan*, Manorma Kumari

Abstract

Acetylcholinesterase (AChE) inhibition and antioxidant activity are considered to be highly correlated with Alzheimerâ�?�?s disease treatment. The present study was designed to investigate the antioxidant and acetylcholinesterase inhibitory activity of Desmodium gangeticum L. Properly identified powdered plant material was extracted successively using methanol as a solvent. Acetylcholinesterase inhibitory activity was measured with modified Ellman method at 405 nm and antioxidant activity measured based on 1, 1- diphenyl-2-picrylhydrazil (DPPH) free radical scavenging test at 517 nm. Percentage inhibition for AChE ranged from 28.78�?±0.12 to 40.83�?±0.05 whereas DPPH radical scavenging percentage ranged from 24.68�?±0.72 to 42.22�?±0.67.

10.21746/ijbio.2017.01.004

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