Cyclodextrin: An overview

Author(s): Nisar Ahmad Khan *, Mohi Durakshan

Abstract

Cyclodextrins are versatile pharmaceutical excipients used to enhance the solubility, stability, safety and bioavailability of drugs. Besides, being used to reduce gastrointestinal drug irritation, convert liquid drugs into microcrystalline or amorphous powder, and prevent drug–drug and drug–excipient interactions, they have shown to display adjuvant activity in vaccine therapy, prophylactic and therapeutic use in the treatment of several host-pathogen infections. Cyclodextrins (CDs) are chemically cyclic oligosaccharides which have been recognized as useful pharmaceutical excipients. The molecular structure of these glucose derivatives generates a hydrophilic exterior surface and a non-polar cavity interior. Such CDs can interact with appropriate size drug molecules which lead to the formation of inclusion complexes A number of CDs based products are available in the market based on their ability to camouflage undesirable physicochemical properties of drugs. Current review enlightens the various aspects of CD’S with regard to their chemical characteristics, properties, approaches used for complexation, characterization techniques, uses along with and future potential.

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